Insight into the reaction between a primary amine and a cavitand with an introverted aldehyde group: an enzyme-like mechanism.
نویسندگان
چکیده
Density functional theory investigations reveal that a cavitand with an introverted aldehyde group not only provides the host-guest interaction for preorganizing the substrate and stabilizing the hemiaminal intermediate, but also acts as an acid/base catalyst in the subsequent dehydration step in its reaction with a primary amine.
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 15 شماره
صفحات -
تاریخ انتشار 2013